Common name: Tebuconazole
IUPAC name: (RS)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol
Chemical Abstracts name:
(±-a-[2-(4-chlorophenyl)ethyl]-a-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol
CAS RN:[107534-96-3]
PHYSICAL CHEMISTRY
Mol. wt.: 307.8
Form:Colourless crystals; (tech., colourless to light brown powder).
M.p.: 105 ºC
V.p.: 1.7 ×10-3 mPa (20 ºC)
Kow logP = 3.7 (20 °C)
Henry: 1×10-5 Pa m3 mol-1 (20 °C)
S.g./density: 1.25 (26 °C)
Solubility In water 36 mg/l (pH 5-9, 20 ºC). In dichloromethane >200, isopropanol, toluene 50-100, hexane <0.1 (all in g/l, 20 ºC).
Stability Stable to elevated temperatures, and to photolysis and hydrolysis in pure water, under sterile conditions; hydrolysis DT50 >1 y (pH 4-9, 22 °C). See also Environmental Fate.
TOXICOLOGY
Oral Acute oral LD50 for male rats 4000, female rats 1700, mice c. 3000 mg/kg.
Skin and eye Acute percutaneous LD50 for rats >5000 mg/kg. Non-irritating to skin; mild irritant to eyes (rabbits).
Inhalation LC50 (4 h) for rats 0.37 mg/l air (aerosol), >5.1 mg/l (dust).
NOEL (2 y) for rats 300, dogs 100, mice 20 mg/kg diet.
ADI (JMPR) 0.03 mg/kg b.w.
Toxicity class WHO (a.i.) III
EPA (formulation) II
EC hazard (Xn; R22)
ECOTOXICOLOGY
Birds Acute oral LD50 for male Japanese quail 4438, female Japanese quail 2912, bobwhite quail 1988 mg/kg b.w. Dietary LC50 (5 d) for mallard ducks >4816, bobwhite quail >5000 mg/kg feed.
Fish LC50 (96 h) for rainbow trout 4.4, bluegill sunfish 5.7 mg/l (flow through).
Daphnia LC50 (48 h) 4.2 mg/l (flow through).
Algae ErC50 (96 h) for Scenedesmus subspicatus 4.01 mg/l (static).
Other aquatic spp. No effect on Chironomus riparius at 0.1 mg/l (28 d).
Bees LD50 (48 h) (oral) 175.8 mg/bee; (contact) 0.6 mg/bee.
Worms Acute LC50 (14 d) for Eisenia foetida 1381 mg/kg dry soil.
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