Common name: Oxadiazon
IUPAC name: 5-tert-butyl-3-(2,4-dichloro-5-isopropoxyphenyl)-1,3,4-oxadiazol-2(3H)-one
Chemical Abstracts name:
3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one
CAS RN:[19666-30-9]
PHYSICAL CHEMISTRY
Mol. wt.: 345.2
Form:Colourless, odourless crystals.
M.p.: 87 ºC
V.p.: 0.1 mPa (25 ºC)
Kow logP = 4.91 (20 °C)
Henry:3.5×10-2 Pa m3 mol-1 (calc.)
Solubility In water 1.0 mg/l (20 ºC). In methanol, ethanol c. 100, cyclohexane 200, acetone, isophorone, methyl ethyl ketone, carbon tetrachloride c. 600, toluene, benzene, chloroform c. 1000 (all in g/l, 20 ºC).
Stability Stable in neutral or acidic medium, relatively unstable in alkali; DT50 38 d (pH 9, 25 °C).
TOXICOLOGY
Oral Acute oral LD50 for rats >5000 mg/kg.
Skin and eye Acute percutaneous LD50 for rats and rabbits >2000 mg/kg. Slightly irritating to eyes; negligible irritant to skin (rabbits).
Inhalation LC50 (4 h) for rats >2.77 mg/l.
NOEL (2 y) In 2 y feeding trials, rats and mice receiving 10 mg/kg diet showed no ill-effects.
Toxicity class WHO (a.i.) III
EPA (formulation) IV
EC hazard N; R50, R53
ECOTOXICOLOGY
Birds Acute oral LD50 (24 d) for mallard ducks >1000, bobwhite quail >2150 mg/kg.
Fish LC50 (96 h) for rainbow trout and bluegill sunfish 1.2 mg/l.
Daphnia EC50 (48 h) >2.4mg/l.
Algae EC50 6-3000 mg/l.
Bees LD50 >400 mg/bee, with repellent effect. Mortality is negligible by direct contact at doses up to 27 kg a.i./ha.
Worms Not toxic at recommended rate.
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