Common name: Carbofuran
IUPAC name: 2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate
Chemical Abstracts name: 2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate
CAS RN:[1563-66-2]
PHYSICAL CHEMISTRY
Mol. wt.: 221.3
Form:Colourless crystals
M.p.: 153-154 ºC; (tech. 150-152 ºC)
V.p.: 0.031 mPa (20 ºC); 0.072 mPa (25 ºC)
Kow logP= 1.52 (20 ºC)
S.g./density: 1.18 (20 ºC)
Solubility In water 320 (20 ºC), 351 (25 °C) (both in mg/l). In dichloromethane >200, isopropanol 20-50, toluene 10-20 (all in g/l, 20 ºC).
Stability Unstable in alkaline media. Stable in acidic and neutral media. Decomposes >150 ºC. DT50 (22 ºC) >>1 y (pH 4), 121 d (pH 7), 31 h (pH 9).
TOXICOLOGY
Oral Acute oral LD50 for male and female rats c. 8, dogs 15, mice 14.4 mg/kg.
Skin and eye Acute percutaneous LD50 (24 h) for male and female rats >2000 mg/kg; mildly irritating to skin and eyes (rabbits).
Inhalation LC50 (4 h) for male and female rats c. 0.075 mg/l air (aerosol).
NOEL (2 y) for rats and mice 20 mg/kg diet; (1 y) for dogs 10 mg/kg diet.
ADI (JMPR) 0.002 mg/kg b.w.
Toxicity class WHO (a.i.) Ib
EPA (formulation) I ('Furadan 4F'), II ('Furadan G')
EC hazard T+; R26/28| N; R50, R53
ECOTOXICOLOGY
Birds Acute oral LD50 for Japanese quail 2.5-5 mg/kg. LC50 for Japanese quail 60-240 mg (as GR5)/kg. Tech.: LC50 0.7-8 mg/kg, depending on species.
Fish LC50 (96 h) for rainbow trout 22-29 mg (as GR5)/l, bluegill sunfish 1.75 mg (as GR3)/l, golden orfe 107-245 mg (as GR5)/l. Tech.: 7.3-362.5 mg/l, depending on species.
Daphnia LC50 (48 h) 38.6 mg/l.
Bees Toxic to bees (except for granular formulation).
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