Common name: Acetamiprid
IUPAC name: (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
Chemical Abstracts name:
(E)-N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide
CAS RN: [135410-20-7]
PHYSICAL CHEMISTRY
Mol. wt.: 222.7
Form:Colourless crystals
M.p.: 98.9 °C
V.p.: <1×10-3 mPa (25 ºC)
Kow logP= 0.80 (25 ºC)
Henry:<5.3×10-8 Pa m3 mol-1 (calc.)
S.g./density: 1.330 (20 °C)
Solubility In water 4250 mg/l (25 ºC). Soluble in acetone, methanol, ethanol, dichloromethane, chloroform, acetonitrile and tetrahydrofuran.
Stability Stable in buffered solutions at pH 4, 5, 7. Degraded slowly at pH 9 and 45 ºC. Stable under sunlight.
TOXICOLOGY
Oral Acute oral LD50 for male rats 217, female rats 146, male mice 198, female mice 184 mg/kg.
Skin and eye Acute percutaneous LD50 for male and female rats >2000 mg/kg. Non-irritating to skin and eyes (rabbits); not a skin sensitiser (guinea pigs).
Inhalation LC50 (4 h) for male and female rats >0.29 mg/l.
NOEL (2 y) for rats 7.1 mg/kg b.w.; (18 mo) for mice 20.3 mg/kg b.w.; (1 y) for dogs 20 mg/kg b.w.
ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail 180 mg/kg. LC50 for bobwhite quail >5000 ppm.
Fish LC50 (24-96 h) for carp >100 mg/l.
Daphnia LC50 (24 h) >200 mg/l.
Algae EC50 (72 h) >98.3 mg/l; NOEC (72 h) 98.3 mg/l.
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