Common name: Tribenuron-methyl
Chemical Abstracts name:
Methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulfonyl]benzoate
CAS RN:[101200-48-0]
PHYSICAL CHEMISTRY
Mol. wt.: 395.4
Form:Light brown, odourless solid.
M.p.: 141 ºC
V.p.: 5.2×10-5 mPa (25 ºC)
Kow logP= -0.44 (pH 7)
Henry:1.03×10-8 Pa m3 mol-1
S.g./density: 1.5 (25 ºC)
Solubility In water 0.05 (pH 5), 2.04 (pH 7) (both in g/l, 20 ºC). In acetone 43.8, acetonitrile 54.2, carbon tetrachloride 3.12, ethyl acetate 17.5, hexane 0.028, and methanol 3.39 (all in mg/l, 25 °C).
Stability Stable at 45 ºC. On hydrolysis (45 ºC), stable at pH 8-10 but rapid loss at pH <7 or pH >12. Relatively unstable in most organic solvents.
TOXICOLOGY
Oral Acute oral LD50 for rats >5000 mg/kg.
Skin and eye Acute percutaneous LD50 for rabbits >2000 mg/kg. Non-irritating to skin (rabbits); mild (reversible) irritant to eyes. Mildly sensitising to skin (guinea pig maximisation test).
Inhalation LC50 (4 h) for rats >5.0 mg/l air.
NOEL (2 y) for rats 25 ppm diet; (18 mo) for mice 200 ppm diet (30 mg/kg b.w. daily); (1 y) for dogs 250 ppm diet (8.2 mg/kg b.w. daily); (90 d) for rats 100, for mice 500, for dogs 500 mg/kg diet. Non-teratogenic in rats at 20 mg/kg daily.
ADI (JMPR) 0.008 mg/kg. Other Non-mutagenic in the Ames test, and negative in CHO, unscheduled DNA, in vivo cytogenetic, in vivo mouse micronucleus, and in vitro human lymphocyte assays.
Toxicity class WHO (a.i.) III
EPA (formulation) III
EC hazard R43
ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail >2250 mg/kg. Dietary LC50 (8 d) for bobwhite quail and mallard ducks >5620 mg/kg.
Fish LC50 (96 h) for bluegill sunfish and rainbow trout >1000 mg/l.
Daphnia LC50 (48 h) 720 mg/l (unfed), 1000 mg/l (fed).
Algae EC50 (120 h) for green algae and blue-green algae >11.5 mg/l.
Bees LD50 for honeybees >100 mg/bee.
Worms LD50 for earthworms >2000 ppm.
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