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Common name: Thiophanate-methyl
IUPAC name: dimethyl 4,4'-(o-phenylene)bis(3-thioallophanate)
Chemical Abstracts name:dimethyl [1,2-phenylenebis(iminocarbonothioyl)]bis[carbamate]
CAS RN:[23564-05-8]
Mol. wt.: 342.4
Form:Colourless crystals.
M.p.: 172 ºC (decomp.)
V.p.: 0.0095 mPa (25 ºC)
Kow logP = 1.50
Solubility Practically insoluble in water (23 ºC). In acetone 58.1, cyclohexanone 43, methanol 29.2, chloroform 26.2, acetonitrile 24.4, ethyl acetate 11.9 (all in g/kg, 23 ºC). Slightly soluble in hexane.
Stability Stable in neutral, aqueous solution at room temperature. Stable to air and sunlight. Quite stable in acidic solution at room temperature; unstable in alkaline solution; DT50 24.5 h (pH 9, 22 ºC). Formulated product is stable ³2 y below 50 ºC.
Oral Acute oral LD50 for male rats 7500, female rats 6640, male mice 3510, male rabbits 2270 mg/kg.
Skin and eye Acute percutaneous  Acute percutaneous LD50 for male and female rats >10 000 mg/kg. Mild skin and eye irritant.
Inhalation  LC50 (4 h) for rats 1.7 mg/l air.
NOEL (2 y) for rats and mice 160 mg/kg diet, for dogs 50 mg/kg diet.
ADI (JMPR) 0.08 mg/kg b.w.
Toxicity class WHO (a.i.) III
EPA (formulation) IV
EC hazard R40| N; R50, R53 
Birds Acute   oral and percutaneous LD50 for Japanese quail >5000 mg/kg.
Fish  LC50 (48 h) for rainbow trout 7.8, carp 11 mg/l.
Daphnia   LC50 (48 h) 20.2 mg/l.
Algae  EC50 (96 h) for Chlorella 0.8 mg/l.
Bees  Not toxic to bees; LD50 (topical) >100 mg/bee.

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