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Flutriafol
Common name: Flutriafol
IUPAC name: (RS)-2,4'-difluoro-a-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol
Chemical Abstracts name:    
(±-a-(2-fluorophenyl)-a-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol
CAS RN:[76674-21-0]
 
PHYSICAL CHEMISTRY
Mol. wt.: 301.3
Form:White, crystalline solid.
M.p.: 130 ºC
V.p.: 7.1×10-6 mPa (20 ºC)
Kow logP= 2.3 (20 ºC)
Henry: 1.65×10-8 Pa m3 mol-1 (calc.)
S.g./density: 1.41 g/ml (25 ºC)
Solubility In water 130 mg/l (pH 7, 20 ºC). In acetone 190, dichloromethane 150, methanol 69, xylene 12, hexane 0.3 (all in g/l, 20 ºC). 
 
TOXICOLOGY
Oral Acute oral  LD50 for male rats 1140, female rats 1480 mg/kg.
Skin and eye Acute percutaneous  LD50 for rats >1000, rabbits >2000 mg/kg. Mild eye irritant; non-irritating to skin (rabbits). Not a skin sensitiser.
Inhalation  LC50 (4 h) for rats >3.5 mg/l.
NOEL In 90 d feeding trials, rats receiving 2 mg/kg diet, and dogs receiving 5 mg/kg daily showed no ill-effects. Non-teratogenic in rats and rabbits.
ADI (JMPR) Non-cytogenic in in vivo studies. Non-mutagenic in the Ames assay.
Toxicity class WHO (a.i.) III
EPA (formulation) III
EC hazard  (Xn; R20/21/22| R52, R53)
 
ECOTOXICOLOGY
Birds Acute oral   LD50 for female mallard ducks >5000 mg/kg. Dietary LC50 (5 d)  for mallard ducks 3940, Japanese quail 6350 mg/kg.
Fish LC50 (96 h) for rainbow trout 61, mirror carp 77 mg/l. NOEC 6.2 mg/l.
Daphnia   LC50 (48 h) 78 mg/l.
Bees  Low toxicity to honeybees. Acute oral LD50 >5 mg/bee.
Worms   LC50 (14 d) >1000 mg/kg.
 

 
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